Epithelial Plasticity in Disease
Phuoc T. Tran*+, Emelyn H. Shroff*, Timothy F. Burns*, Saravanan Thiyagarajan, Sandhya T. Das, Tahera Zabuawala, Joy Chen, Yoon-Jae Cho, Richard Luong, Pablo Tamayo, Tarek Salih, Khaled Aziz, Stacey J. Adam, Silvestre Vicent, Carsten H. Nielsen, Nadia Withofs, Alejandro Sweet-Cordero, Sanjiv S. Gambhir, Charles M. Rudin and Dean W. Felsher+. Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis. PLoS Genet 8 (2012) e1002650. PMID: 22654667; PMCID: PMC3360067.
* - these authors contributed equally.
+ - corresponding authors.
Timothy F. Burns, Irina Dobromilskaya, Sara C. Murphy, Rajendra P. Gajula, Saravanan Thiyagarajan, Sarah S. Chatley, Khaled Aziz, Yoon-Jae Cho, Phuoc T. Tran, Charles M. Rudin. Inhibition of TWIST1 Leads to Activation of Oncogene-Induced Senescence in Oncogene Driven Non-Small Cell Lung Cancer. Mol Cancer Res 11 (2013) 329-338. PMID: 23364532. PMCID: PMC3631276.
Rajendra P. Gajula*, Sivarajan T. Chettiar*, Russell D. Williams, Saravanan Thiyagarajan, Yoshinori Kato, Khaled Aziz, Ruoqi Wang, Nishant Gandhi, Aaron T. Wild, Farhad Vesuna, Jinfang Ma, Tarek Salih, Jessica Cades, Elana Fertig, Shyam Biswal, Timothy F. Burns, Christine Chung, Charles M. Rudin, Joseph M. Herman, Russell K. Hales, Venu Raman, Steven An, Phuoc T. Tran. The twist box domain is required for Twist1-induced prostate cancer metastasis. Mol Cancer Res 11 (2013) 1387-1400**. PMID: 23982216. PMCID: PMC3833995.
* - these authors contributed equally.
** - Cover illustration and Highlighted in Mol Cancer Res.
Eliah R. Shamir, Elisa Pappalardo, Danielle M. Jorgens, Kester Coutinho, Wen-Ting Tsai, Khaled Aziz, Manfred Auer, Phuoc T. Tran, Joel S. Bader, Andrew J. Ewald. Twist1-induced dissemination preserves epithelial identity and requires E-cadherin. J Cell Biol 204 (2014) 839-856**. PMID 24590176; PMCID: PMC3941052.
** - Cover illustration and Highlighted in J Cell Biol; rated Exceptional by Faculty of 1000 (http://f1000.com/prime/718297809).
Rajendra P. Gajula*, Sivarajan T. Chettiar*, Russell D. Williams, Katriana Nugent, Yoshinori Kato, Hailun Wang, Reem Malek, Kekoa Taparra, Jessica Cades, Anvesh Annadanam, A-Rum Yoon, Elana Fertig, Beth A. Firulli, Lucia Mazzacurati, Timothy F. Burns, Anthony B. Firulli, Steven An, Phuoc T. Tran. Structure-function studies of the bHLH phosphorylation domain of Twist1 in prostate cancer cells. Neoplasia 17 (2015) 16-31. PMID: 25622896. PMCID: PMC4309734.
* - these authors contributed equally.
Kekoa A. Taparra, Phuoc T. Tran, Natasha Zachara. Hijacking the hexosamine biosynthetic pathway to promote epithelial-mesenchymal transition-mediated neoplastic phenotypes. Front Oncol 6 (2016) 85. PMID: 27148477. PMCID: PMC4834358. PMCID: PMC4834358.
Reem Malek*, Hailun Wang*, Kekoa Taparra, Phuoc T. Tran. Therapeutic targeting of epithelial plasticity programs – Focus on the epithelial-mesenchymal transition. Cells Tissues Organs 203 (2017) 114-127. PMID: 28214899.
* - these authors contributed equally
Reem Malek*, Rajendra P. Gajula*, Russell D. Williams*, Belinda Nghiem, Brian W. Simons, Katriana Nugent, Hailun Wang, Kekoa Taparra, Ghali Lemtiri-Chlieh, A-Rum Yoon, Lawrence True, Steven S. An, Theodore L. DeWeese, Ashley Ross, Edward M. Schaeffer, Kenneth J. Pienta, Paula J. Hurley, Colm Morrissey, Phuoc T. Tran. TWIST1-WDR5-Hottip regulates Hoxa9 chromatin to facilitate prostate cancer metastasis. Cancer Res 77 (2017) 3181-3193**. PMID 28484075. PMCID: PMC5489316.
* - these authors contributed equally.
** - Highlighted in Cancer Res – Breaking Advances.
Zachary A. Yochum*, Jessica A. Cades*, Lucia Mazzacurati, Neil Neumann, Susheel Khetarpal, Suman Chatterjee, Hailun Wang, Myriam Attar, Eric Huang, Sarah Chatley, Katriana Nugent, Ashwin Somasundaram, Johnathan Engh, Andrew Ewald, Yoon-Jae Cho, Charles M. Rudin, Phuoc T. Tran, Timothy F. Burns. A First-in-Class TWIST1 inhibitor with Activity in Oncogene-driven Lung Cancer. Mol Cancer Res 15 (2017) 1764-1776. PMID 28851812.
* - these authors contributed equally.
Kekoa Taparra*, Hailun Wang*, Reem Malek*, Audrey Lafargue, Mustafa A. Barbhuiya, Xing Wang, Brian W. Simons, Matthew Ballew, Katriana Nugent, Jennifer Groves, Russell D. Williams, Takumi Shiraishi, James Verdone, Gokben Yildirir, Roger Henry, Bin Zhang, John Wong, Ken K. Wang, Barry D. Nelkin, Kenneth J. Pienta, Dean Felsher, Natasha E. Zachara+, Phuoc T. Tran+. O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis. J Clin Invest 128 (2018) 4924-4937**. PMID 30130254. PMCID: PMC6205381.
* - these authors contributed equally.
+ - corresponding authors.
** - Highlighted in Cancer Res – Breaking Advances.
Zachary A. Yochum*, Jessica Cades*, Hailun Wang*, Suman Chatterjee, Brian W. Simons, James P. O'Brien, Susheel K. Khetarpal, Ghali Lemtiri-Chlieh, Kayla V. Myers, Eric H.-B. Huang, Charles M. Rudin, Phuoc T. Tran+, Timothy F. Burns+. Targeting the EMT transcription factor TWIST1 overcomes resistance to EGFR inhibitors in EGFR-mutant non-small cell lung cancer. Oncogene 38 (2019) 656-670. PMID 30171258. PMCID: PMC6358506.
* - these authors contributed equally.
+ - corresponding authors.
Renumathy Dhanasekaran*, Virginie Baylot*, Minsoon Kim, Sibu Kuruvilla, David I. Bellovin, Nia Adeniji, Anand Rajan KD, Ian Lai, Meital Gabay, Ling Tong, Maya Krishnan, Jangho Park, Theodore Hu, Mustafa A. Barbhuiya, Andrew Gentles, Kasthuri Kannan, Phuoc T. Tran+, Dean W. Felsher+. MYC and Twist1 cooperate to drive metastasis by eliciting crosstalk between cancer and innate immunity.
eLife 9 (2020) e50731**. PMID: 31933479.
*, + - these authors contributed equally
** - Highlighted in Cancer Res – Breaking Advances.
Fernando Eguiarte-Solomon, Nicholas Blazanin, Okkyung Rho, Steve Carbajal, Dean W. Felsher, Phuoc T. Tran, John DiGiovanni. Twist1 is Required for Development of UVB-Induced Squamous Cell Carcinoma. Mol Carcinog 60 (2021) 342-353. PMID 33713497.
Eleanor Valenzi*, Harinath Bahudhanapati*, Jiangning Tan, Tracy Tabib, Daniel I. Sullivan, Mehdi Nouraie, John Sembrat, Li Fan, Kong Chen, Silvia Liu, Mauricio Rojas, Audrey Lafargue, Dean W. Felsher, Phuoc T. Tran, Daniel J. Kass+, Robert Lafyatis+. Single-Nucleus Chromatin Accessibility Identifies a Critical Role for TWIST1 in Idiopathic Pulmonary Fibrosis Myofibroblast Activity. Eur Respir J 62 (2023) 2200474**. PMID: 37142338.
* - these authors contributed equally; and + - corresponding authors
** - Highlighted by Editorial in Eur Respir J (PMID 37419523).
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Molecular Targeted Therapies, Immunotherapies and Radiosensitizers
Phuoc T. Tran*, Pavan K. Bendapudi*, H. Jill Lin*, Peter Choi, Shan Koh, Joy Chen, George Horng, Nicholas P. Hughes, Lawrence H. Schwartz, Vincent A. Miller, Toshiyuki Kawashima, Toshio Kitamura, David Paik+ and Dean W. Felsher+. Survival and Death Signals Can Predict Tumor Response to Therapy After Oncogene Inactivation. Sci Transl Med 3 (2011) 103ra99**. PMID: 21974937; PMCID: PMC3966995.
* - these authors contributed equally; and + - corresponding authors.
** - Highlighted by Comments in Sci Transl Med, Cancer Res, Nat Rev Clin Oncol and Cancer Discovery
Jing Zeng, Khaled Aziz, Sivarajan T. Chettiar, Blake Aftab, Michael Armour, Rajendra Gajula, Nishant Gandhi, Tarek Salih, Joseph M. Herman, John Wong, Charles M. Rudin, Phuoc T. Tran, Russell K. Hales. Hedgehog pathway inhibition radiosensitizes non-small cell lung cancers. Int J Radiat Oncol Biol Phys 86 (2013) 143-149. PMID: 23182391. PMCID: PMC4145860.
Nishant Gandhi*, Aaron T. Wild*, Sivarajan T. Chettiar, Khaled Aziz, Yoshinori Kato, Rajendra P. Gajula, Russell D. Williams, Jessica Cades, Anvesh Annadanam, Danny Song, Yonggang Zhang, Russell K. Hales, Joseph M. Herman, Theodore L. DeWeese, Edward M. Schaeffer, Phuoc T. Tran. Novel Hsp90 inhibitor NVP-AUY922 radiosensitizes prostate cancer cells. Cancer Biol Ther 14 (2013) 347-356. PMID: 23358469.
* - these authors contributed equally
Jing Zeng, Timothy J. Harris, Michael Lim, Charles G. Drake, Phuoc T. Tran. Immune Modulation and Stereotactic Radiation – Improving Local and Abscopal Responses. Biomed Res Int 2013 (2013). 658126. PMID: 24324970; PMCID: PMC3845488
Jing Zeng, Alfred P. See, Jillian Phallen, Christopher M. Jackson, Zineb Belcaid, Jacob Ruzevick, Nicholas Durham, Christian Meyer, Timothy J. Harris, Emilia Albesiano, Gustavo Pradilla, Eric Ford, John Wong, Hans Hammers, Dimitris Mathios, Betty Tyler, Henry Brem, Phuoc T. Tran, Drew Pardoll, Charles G. Drake, Michael Lim. Anti-PD-1 blockade and stereotactic radiation produce long term survivors in mice with intracranial gliomas. Int J Radiat Oncol Biol Phys 86 (2013) 343-349**. PMID: 23462419; PMCID: PMC3963403.
** - #2 “Top Download” biology paper from Int J Radiat Oncol Biol Phys in 2013 (http://www.redjournal.org/article/S0360-3016(14)00577-X/fulltext).
Aaron T. Wild*, Nishant Gandhi*, Sivarajan T. Chettiar, Khaled Aziz, Rajendra P. Gajula, Russell D. Williams, Rachit Kumar, Kekoa Taparra, Jing Zeng, Jessica A, Cades, Esteban Velarde, Siddharth Menon, Jean-Francois Geschwind, David Cosgrove, Timothy M. Pawlik, Anirban Maitra, John Wong, Russell K. Hales, Michael Torbenson, Joseph M. Herman+, Phuoc T. Tran+. Concurrent versus sequential sorafenib therapy in combination with radiation for hepatocellular carcinoma. PLoS ONE 8 (2013) e65726. PMID: 23762417. PMCID: PMC3675179.
* - these authors contributed equally; and + - corresponding authors.
Guus Martinus Bol, Farhad Vesuna, Min Xie, Jing Zeng, Khaled Aziz, Nishant Gandhi, Anne Levine, Ashley Irving, Dorian Korz, Saritha Tantravedi, Marise Heerma van Voss, Kathleen Gabrielson, Evan A. Bordt, Brian M. Polster, Leslie Cope, Petra van der Groep, Atul Kondaskar, Michelle A. Rudek, Ramachandra S. Hosmane, Elsken van der Wall, Paul Joannes van Diest, Phuoc T. Tran, Venu Raman. Targeting DDX3 with a small molecule inhibitor for lung cancer therapy. EMBO Mol Med 7 (2015) 648-669**. PMID: 25820276. PMCID: PMC4492822.
** - Highlighted in Cancer Res – Breaking Advances.
Sivarajan T. Chettiar*, Reem Malek*, Anvesh Annadanam*, Katriana Nugent, Yoshinori Kato, Hailun Wang, Jessica A. Cades, Kekoa Taparra, Zineb Belcaid, Matthew Ballew, Sarah Manmiller, David Proia, Michael Lim, Robert Anders, Joseph M. Herman, Phuoc T. Tran. Ganetespib radiosensitization for liver cancer therapy. Cancer Biol Ther 17 (2016) 457-66. PMID: 26980196.
* - these authors contributed equally
Zachary A. Yochum*, Jessica A. Cades*, Lucia Mazzacurati, Neil Neumann, Susheel Khetarpal, Suman Chatterjee, Hailun Wang, Myriam Attar, Eric Huang, Sarah Chatley, Katriana Nugent, Ashwin Somasundaram, Johnathan Engh, Andrew Ewald, Yoon-Jae Cho, Charles M. Rudin, Phuoc T. Tran, Timothy F. Burns. A First-in-Class TWIST1 inhibitor with Activity in Oncogene-driven Lung Cancer. Mol Cancer Res 15 (2017) 1764-1776. PMID 28851812.
* - these authors contributed equally.
Mustafa A. Barbhuiya*, Adam C. Mirando*, Brian W. Simons, Ghali Lemtiri-Chlieh, Jordan J. Green, Aleksander S. Popel+, Niranjan B. Pandey+, Phuoc T. Tran+. Therapeutic potential of an anti-angiogenic multimodal biomimetic peptide in hepatocellular carcinoma. Oncotarget 8 (2017) 101520-101534. PMID 29254183. PMCID: PMC5731893.
* - these authors contributed equally; and + - corresponding authors.
Ariel Marciscano*, Heather McGee*, Joseph Walker*, Michelle Kim, Charles Kunos, Arta Monjazeb, Stephen Shiao, Phuoc T. Tran+, Mansoor Ahmed+. Incorporating Radiation Oncology into Immunotherapy: Proceedings from the ASTRO-SITC-NCI Immunotherapy Workshop. J Immunother Cancer 6 (2018) 6. PMID: 29375032. PMCID: PMC5787916.
* - these authors contributed equally; and + - corresponding authors.
Robert Bristow, Brian Alexander, Michael Baumann, Scott V. Bratman, Martin Brown, Kevin Camphausen, Peter Choyke, Deborah Citrin, Joseph Contessa, Adam Dicker, David G. Kirsch, Mechthild Krause, Quynh Le, Michael Milosevic, Zachary Morris, Jann Sarkaria, Paul Sondel, Phuoc T. Tran, George Wilson, Henning Willers, Rebecca Wong, Paul M. Harari. Combining Precision Radiotherapy with Molecular Targeting and Immunomodulatory Agents. Lancet Oncol 19 (2018) e240-e251. PMID: 29726389
Saif S. Ahmad, Marka Crittenden, Phuoc T. Tran, Paul Kluetz, Gideon Blumenthal, Helen Bulbeck, Richard D. Baird, Kaye J. Williams, Timothy Illidge, Stephen M. Hahn, Theodore S. Lawrence, Patricia A. Spears, Amanda J. Walker+, Ricky A. Sharma+. Clinical Development of Novel Drug-Radiotherapy Combinations. Clin Cancer Res 25 (2019). 1455-1461. PMID: 30498095. PMCID: PMC6397668.
+ - corresponding authors
Ashley E. Ross, Paula J. Hurley, Phuoc T. Tran, Steven Rowe, Benjamin Benzon, Tanya O’Neal, Carolyn Chapman, Rana Harb, Yelena Milman, Charles G. Drake, Emmanuel S. Antonarakis. A Pilot Clinical Trial of Pembrolizumab plus Prostatic Cryotherapy for Men with Newly Diagnosed Oligometastatic Hormone-Sensitive Prostate Cancer. Prostate Cancer Prostatic Dis 23 (2020) 184-193. PMID: 31611635.
Xing Wang*, Natasha Raman*, Ghali Lemtiri-Chlieh*, Jinhee Chang, Shreya Jagtap, Dipanwita Dutta Chowdhury, Matthew Ballew, Francesca Carrieri, Triet Nguyen, Katriana Nugent, Travis Peck, Michelle S. Levine, Aaron Chan, Christine Lam, Reem Malek, Tung Hoang, Ryan Phillips, ZhuoAn Cheng, Kekoa Taparra, Nick Connis, Christine L. Hann, Andrew Holland, Phuoc T. Tran, Audrey Lafargue+, Hailun Wang+. Griseofulvin Radiosensitizes Non-Small Cell Lung Cancer Cells and Activates cGAS. Mol Cancer Ther 22 (2023) 519-528. PMID: 36752776. PMCID: PMC10073282.
* - these authors contributed equally; and + - corresponding authors
Back to Top
Small Animal Models, Imaging and Irradiation
Hu Zhou, Manuel Rodriguez, Fred van den Haak, Geoffrey Nelson, Rahil Jogani, Jiali Xu, Xinzhi Zhu, Yongjiang Xian, Phuoc T. Tran, Dean W. Felsher, Paul J. Keall, Edward E. Graves. Development of a MicroCT-Based Image-Guided Conformal Radiotherapy System for Small Animals. Int J Radiat Oncol Biol Phys 78 (2010)297-305. PMID: 20395069; PMCID: PMC2906632.
Edward E. Graves, Marta Vilalta, Ivana K. Cecic, Janine T. Erler, Phuoc T. Tran, Dean Felsher, Leanne Sayles, Alejandro Sweet-Cordero Quynh-Thu Le and Amato J. Giaccia. Hypoxia in models of lung cancer: implications for targeted therapeutics. Clin Cancer Res 16 (2010) 4843-52. PMID: 20858837; PMCID: PMC2948600.
Carsten H. Nielsen, Richard H Kimura, Nadia Withofs, Phuoc T. Tran, Zheng Miao, Jennifer Cochran, Zhen Cheng, Dean Felsher, Andreas Kjaer, Juergen K. Willmann, Sanjiv S. Gambhir. PET Imaging of Tumor Neovascularization in a Transgenic Mouse Model with a Novel 64Cu-DOTA-Knottin Peptide. Cancer Res 70 (2010) 9022-30. PMID: 21062977; PMCID: PMC3057960.
Phuoc T. Tran*, Pavan K. Bendapudi*, H. Jill Lin*, Peter Choi, Shan Koh, Joy Chen, George Horng, Nicholas P. Hughes, Lawrence H. Schwartz, Vincent A. Miller, Toshiyuki Kawashima, Toshio Kitamura, David Paik+ and Dean W. Felsher+. Survival and Death Signals Can Predict Tumor Response to Therapy After Oncogene Inactivation. Sci Transl Med 3 (2011) 103ra99**. PMID: 21974937; PMCID: PMC3966995.
* - these authors contributed equally; and + - corresponding authors.
** - Highlighted by Comments in Sci Transl Med, Cancer Res, Nat Rev Clin Oncol and Cancer Discovery
Phuoc T. Tran*+, Emelyn H. Shroff*, Timothy F. Burns*, Saravanan Thiyagarajan, Sandhya T. Das, Tahera Zabuawala, Joy Chen, Yoon-Jae Cho, Richard Luong, Pablo Tamayo, Tarek Salih, Khaled Aziz, Stacey J. Adam, Silvestre Vicent, Carsten H. Nielsen, Nadia Withofs, Alejandro Sweet-Cordero, Sanjiv S. Gambhir, Charles M. Rudin and Dean W. Felsher+. Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis. PLoS Genet 8 (2012) e1002650. PMID: 22654667; PMCID: PMC3360067.
* - these authors contributed equally; and + - corresponding authors.
Bin Zhang, Ken Kang-Hsin Wang, Jingjing Yu, Sohrab Eslami, Phuoc T. Tran, Iulian Iordachita, Michael S. Patterson, John W. Wong. Bioluminescence tomography guided radiation therapy for preclinical research. Int J Radiat Oncol Biol Phys 94 (2016) 1144-53**. PMID: 26876954. PMCID: PMC4814325.
** - Highlighted in Medical Physics Web (http://medicalphysicsweb.org/cws/article/research/64139).
Kekoa Taparra*, Hailun Wang*, Reem Malek*, Audrey Lafargue, Mustafa A. Barbhuiya, Xing Wang, Brian W. Simons, Matthew Ballew, Katriana Nugent, Jennifer Groves, Russell D. Williams, Takumi Shiraishi, James Verdone, Gokben Yildirir, Roger Henry, Bin Zhang, John Wong, Ken K. Wang, Barry D. Nelkin, Kenneth J. Pienta, Dean Felsher, Natasha E. Zachara+, Phuoc T. Tran+. O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis. J Clin Invest 128 (2018) 4924-4937**. PMID 30130254. PMCID: PMC6205381.
* - these authors contributed equally.
+ - corresponding authors.
** - Highlighted in Cancer Res – Breaking Advances.
Zachary A. Yochum*, Jessica Cades*, Hailun Wang*, Suman Chatterjee, Brian W. Simons, James P. O'Brien, Susheel K. Khetarpal, Ghali Lemtiri-Chlieh, Kayla V. Myers, Eric H.-B. Huang, Charles M. Rudin, Phuoc T. Tran+, Timothy F. Burns+. Targeting the EMT transcription factor TWIST1 overcomes resistance to EGFR inhibitors in EGFR-mutant non-small cell lung cancer. Oncogene 38 (2019) 656-670. PMID 30171258. PMCID: PMC6358506.
* - these authors contributed equally.
+ - corresponding authors.
Renumathy Dhanasekaran*, Virginie Baylot*, Minsoon Kim, Sibu Kuruvilla, David I. Bellovin, Nia Adeniji, Anand Rajan KD, Ian Lai, Meital Gabay, Ling Tong, Maya Krishnan, Jangho Park, Theodore Hu, Mustafa A. Barbhuiya, Andrew Gentles, Kasthuri Kannan, Phuoc T. Tran+, Dean W. Felsher+. MYC and Twist1 cooperate to drive metastasis by eliciting crosstalk between cancer and innate immunity.
eLife 9 (2020) e50731**. PMID: 31933479.
*, + - these authors contributed equally
** - Highlighted in Cancer Res – Breaking Advances.
Devin Miles, Daniel Sforza, John W. Wong, Kathleen Gabrielson, Khaled Aziz, Mahadevappa Mahesh, Jonathan B Coulter, Ismaeel Siddiqui, Phuoc T. Tran, Akila Viswanathan, Mohammad Rezaee. FLASH effects induced by orthovoltage x-rays: FLASH with x-ray tubes - an in vivo study. Int J Radiat Oncol Biol Phys 117 (2023) 1018-1027. PMID: 37364800.
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Clinical-Translational Studies
Phuoc T. Tran+, Russell K. Hales, Jing Zeng, Khaled Aziz , Tarek Salih, Rajendra P. Gajula, Sivarajan Chettiar, Nishant Gandhi, Aaron T. Wild, Rachit Kumar, Joseph M. Herman, Danny Song and Theodore L. DeWeese. Tissue Biomarkers for Prostate Cancer Radiation Therapy. Curr Mol Med 12 (2012) 772-787. PMID: 22292443; PMCID: PMC3412203.
+ - corresponding author.
Nicholas Trakul, Christine Chang, Jeremy Harris, Christopher H. Chapman, Aarti Rao, John Shen, Sean Quinlan-Davidson, Edith J. Filion, Heather Wakelee, A. Dimitrios Colevas, Richard I. Whyte, Sonja Dieterich, Peter G. Maxim, Phuoc Tran, Quynh-Thu Le, Billy W. Loo, Jr., Maximilian Diehn. Tumor volume-adapted dosing in stereotactic ablative radiotherapy of lung tumors. Int J Radiat Oncol Biol 84 (2012) 231-7. PMID: 22381907.
Joseph M. Herman*, Aaron T. Wild*, Hao Wang, Phuoc T. Tran, Kenneth J. Chang, Gretchen E. Taylor, Ross C. Donehower, Timothy M. Pawlik, Mark A. Ziegler, Hongyan Cai, Dionne T. Savage, Yolanda M. Davis, Marcia I. Canto, Jason Klapman, Anthony Reid, Raj J. Shah, Sarah E Hoffe, Alexander Rosemurgy, Christopher L. Wolfgang, Daniel A. Laheru. A randomized phase III multi-institutional study of TNFerade™ biologic with 5-fluorouracil and radiotherapy for locally advanced pancreatic cancer: Final results. J Clin Oncol 31 (2013) 886-894. PMID: 23341531. PMCID: PMC4820756.
* - these authors contributed equally
Wolfgang Lilleby*, Amol Narrang*, Gunnar Tafjord, Ljiljana Vlatkovic, Kjell Magne Russnes, Andreas Stensvold, Knut Håkon Hole, Phuoc Tran, Karsten Eilertsen. Favorable outcomes in locally advanced and node positive prostate cancer patients treated with combined pelvic IMRT and androgen deprivation therapy. Radiat Oncol 10 (2015) 232. PMID: 26577452. PMCID: PMC4650510.
* - these authors contributed equally
Andrew J. Armstrong, Susan Halabi, Patrick Healy, W. Robert Lee, Bridget F. Koontz, Judd W. Moul, Kelly Mundy, Patricia Creel, Sarah Yenser Wood, Kristen Davis, Michael A. Carducci, Mark N. Stein, Brooke Reimer, Avery N. Spitz, Minh Nguyen, Ellen Bratt, Sung Kim, Phuoc T. Tran, Daniel J. George. A phase 2 multimodality trial of docetaxel/prednisone with sunitinib followed by salvage radiation therapy in men with PSA recurrent prostate cancer after radical prostatectomy. Prostate Cancer Prostatic Dis 19 (2016) 100-106. PMID: 26754260.
Jeffrey J. Tosoian, Michael A. Gorin, Ashley E. Ross, Kenneth J. Pienta, Phuoc T. Tran, Edward M. Schaeffer. Oligometastatic Prostate Cancer: Definitions, Clinical Outcomes, and Treatment Considerations. Nat Rev Urol 14 (2017) 15-25. PMID: 27725639.
Phuoc T. Tran, Emmanuel S. Antonarakis. Altering the natural history of oligometastatic prostate cancer with local therapies: Reality versus Illusion. J Oncol Pract 13 (2017) 21-24. PMID: 28045614. PMCID: PMC5455151.
Elise De Bleser, Phuoc T. Tran, Piet Ost. Radiotherapy as metastasis-directed therapy for oligometastatic prostate cancer. Curr Opin Urol 27 (2017) 587-595. PMID: 28816714.
Jonathan Hayman*, Ryan Phillips*, Di Chen, Jamie Perin, Amol K. Narang, Janson Trieu, Noura Radwan, Stephen Greco, Curtiland DeVille, Todd McNutt, Daniel Y. Song, Theodore L. DeWeese, Phuoc T. Tran. Detectable end of radiation prostate specific antigen assists in identifying men with unfavorable intermediate-risk prostate cancer at high risk of distant recurrence and cancer-specific mortality. Prostate 78 (2018) 623-30. PMID 29520847.
* - these authors contributed equally
C. Leigh Moyer, Ryan Phillips, Matthew P. Deek, Noura Radwan, Ashley E. Ross, Emmanuel S. Antonarakis, Diane Reyes, Jean Wright, Stephanie A. Terezakis, Daniel Y. Song, Curtiland DeVille, Patrick C. Walsh, Theodore L. DeWeese, Michael Carducci, Edward M. Schaeffer, Kenneth J. Pienta, Mario Eisenberger+, Phuoc T. Tran+. Stereotactic Ablative Radiation Therapy for Oligometastatic Prostate Cancer Delays Time to Next Systemic Treatment. World J Urol 37** (2019) 2623-2629. PMID 30191396. PMCID: PMC6401357.
+ - corresponding authors
** - Special "Developments in Oligometastatic Hormone-Sensitive Prostate Cancer" issue in World J Urol.
Matthew P. Deek*, Colburn Yu*, Ryan Phillips, Daniel Y. Song, Curtiland DeVille, Stephen Greco, Theodore L. DeWeese, Emmanuel S. Antonarakis, Mark Markowski, Channing Paller, Samuel Denmeade, Michael Carducci, Patrick C. Walsh, Kenneth J. Pienta, Mario Eisenberger, Phuoc T. Tran. Radiotherapy in the definitive management of oligometastatic prostate cancer: the Johns Hopkins experience. Int J Radiat Oncol Biol Phys 105 (2019) 948-956**. PMID: 31419509.
* - these authors contributed equally.
** - Highlighted on a visual abstract by the Int J Radiat Oncol Biol Phys and #7 “Top Download” paper from Int J Radiat Oncol Biol Phys in 2019.
Hamza Hasan*, Matthew P. Deek*, Ryan Phillips, Robert F. Hobbs, Reem Malek, Noura Radwan, Ana P. Kiess, Shirl Dipasquale, James Huang, Terry Caldwell, Jessica Leitzel, Danielle Wendler, Hao Wang, Elizabeth Thompson, Jonathan Powell, Sara Dudley, Curtiland DeVille, Stephen Greco, Daniel Y. Song, Theodore L. DeWeese, Michael A. Gorin, Steven P. Rowe, Sam Denmeade, Mark Markowski, Emmanuel S. Antonarakis, Michael A. Carducci, Mario A. Eisenberger, Martin G. Pomper, Kenneth J. Pienta, Channing J. Paller, Phuoc T. Tran. A phase II randomized trial of RAdium-223 and SABR Versus SABR for oligomEtastatic prostate caNcerS (RAVENS). BMC Cancer 20 (2020) 492. PMID 32487038.
* - these authors contributed equally
Dianne K. Reyes, Steven P. Rowe, Edward M. Schaeffer, Mohammed E. Allaf, Ashley E. Ross, Christian P. Pavlovich, Curtiland Deville, Phuoc T. Tran, Kenneth J. Pienta. Multidisciplinary Total Eradication Therapy (TET) in men with newly diagnosed oligometastatic prostate cancer. Med Oncol 37 (2020) 60. PMID 32524295.
Ashley E. Ross, Paula J. Hurley, Phuoc T. Tran, Steven Rowe, Benjamin Benzon, Tanya O’Neal, Carolyn Chapman, Rana Harb, Yelena Milman, Charles G. Drake, Emmanuel S. Antonarakis. A Pilot Clinical Trial of Pembrolizumab plus Prostatic Cryotherapy for Men with Newly Diagnosed Oligometastatic Hormone-Sensitive Prostate Cancer. Prostate Cancer Prostatic Dis 23 (2020) 184-193. PMID: 31611635.
Ryan Phillips, William Yue Shi, Matthew Deek, Noura Radwan, Su Jin Lim, Emmanuel S. Antonarakis, Steven P. Rowe, Ashley Ross, Michael A. Gorin, Curtiland Deville, Stephen C Greco, Hailun Wang, Samuel R. Denmeade, Channing J. Paller, Shirl Dipasquale, Theodore L. DeWeese, Daniel Y. Song, Hao Wang, Michael A. Carducci, Kenneth J. Pienta, Martin G. Pomper, Adam P. Dicker, Mario A. Eisenberger, Ash A. Alizadeh, Maximilian Diehn, Phuoc T. Tran. Outcomes of Observation versus stereotactic ablative RadiatIon for OLigometastatic prostate CancEr – The ORIOLE Phase 2 Randomized Clinical Trial. JAMA Oncol 6 (2020) 650-659**. PMID 32215577. PMCID: PMC7225913.
** - Editorial in JAMA Oncol, Ranked by Altmetric in top 10% of JAMA Oncol papers (https://jamanetwork.altmetric.com/details/78396760#score) & Highlighted in Cancer Discovery, Cancer Research, Nat Rev Urol and the AACR Cancer Progress Report 2020.
Full Protocol
Matthew P. Deek*, Kekoa Taparra*, Ryan Phillips, Pedro Isaacsson Velho, Robert W. Gao, Curtiland Deville, Daniel Y. Song, Stephen Greco, Michael Carducci, Mario Eisenberger, Theodore L. DeWeese, Samuel Denmeade, Kenneth Pienta, Channing Paller, Emmanuel S. Antonarakis, Kenneth R. Olivier, Sean S. Park, Phuoc T. Tran, Bradley J. Stish. Metastasis Directed-Therapy Prolongs Efficacy of Systemic Therapy and Improves Clinical Outcomes in Oligoprogressive Castration-Resistant Prostate Cancer. Eur Urol Oncol 4 (2021) 447-455**. PMID 32536574. PMCID: PMC7788526.
* - these authors contributed equally.
** - European Urology Oncology SoMe Award ranked by PlumX metrics as the most influential article in this issue
Felix Y Feng+, Huei-Chung (Rebecca) Huang, Daniel E. Spratt, Howard M Sandler, Jeffrey P Simko, Elai Davicioni, Paul L Nguyen, Alan Pollack, Jason A Efstathiou, Adam P Dicker, Rajdeep Das, James Dignam, Darby JS Thompson, Shuang Zhao, Tamara Todorovic, Jennifer Margrave, Yang Liu, Bashar Dabbas, Christopher J. Sweeney, Gerhardt Attard, Jean-Paul Bahary, Himanshu R Lukka, William A Hall, Thomas M Pisansky, Amit B Shah, Stephanie L Pugh, William U Shipley, Phuoc T Tran+. Validation of a 22-Gene Genomic Classifier in Patients with Recurrent Prostate Cancer: An Ancillary Study of the NRG/RTOG 9601 Randomized Clinical Trial. JAMA Oncol 7 (2021) 544-552**. PMID 33570548. PMCID: PMC7879385.
+ - corresponding authors
** - Editorial in and Ranked by Altmetric in top 10% of all papers (https://jamanetwork.altmetric.com/details/99977450#score). NRG Oncology Semi-annual meeting Outstanding Publication Award (February 2022).
Matthew P. Deek*, Kim Van der Eecken*, Philip Sutera, Rebecca A. Deek, Dries Reynders, Valérie Fonteyne, Adrianna A. Mendes, Karel Decaestecker, Ana Ponce Kiess, Nicolaas Lumen, Ryan Phillips, Aurélie De Bruycker, Mark Mishra, Zaker Rana, Jason Molitoris, Bieke Lambert, Louke Delrue, Hailun Wang, Kathryn Lowe, Sofie Verbeke, Jo Van Drope, Renée Bultijnck, Geert Villeirs, Kathia De Man, Filip Ameye, Daniel Y. Song, Theodore DeWeese, Channing J. Paller, Felix Y. Feng, Alexander Wyatt, Kenneth J. Pienta, Maximillian Diehn, Søren M. Bentzen, Steven Joniau, Friedl Vanhaverbeke, Gert De Meerleer, Emmanuel S. Antonarakis, Tamara L. Lotan, Alejandro Berlin, Shankar Siva, Piet Ost+, Phuoc T. Tran+. Long Term Outcomes and Genetic Predictors of Response to Metastasis-Directed Therapy versus Observation in Oligometastatic Prostate Cancer: Analysis of STOMP and ORIOLE Trials. J Clin Oncol 40 (2022) 3377-3382**. PMID: 36001857.
* - these authors contributed equally; and + - corresponding authors
** - Ranked by Altmetric in top 10% of J Clin Oncol papers (https://asco.altmetric.com/details/134945518#score).
Phuoc T. Tran*,+, Kathryn Lowe*, Hua-Ling Tsai, Daniel Y. Song, Arthur Y. Hung, Jason W.D. Hearn, Steven Miller, James A. Proudfoot, Matthew P. Deek, Ryan Phillips, Tamara Lotan, Channing J. Paller, Catherine H. Marshall, Mark Markowski, Shirl Dipasquale, Samuel Denmeade, Michael Carducci, Mario Eisenberger, Theodore L. DeWeese, Matthew Orton, Curtiland Deville, Elai Davicioni, Stanley Liauw, Elisabeth I. Heath, Stephen Greco, Neil B. Desai, Daniel E. Spratt, Felix Feng, Hao Wang, Tomasz M. Beer, Emmanuel S. Antonarakis+. Phase 2 Randomized Study of Salvage Radiation Therapy Plus Enzalutamide or Placebo for High-Risk PSA-Recurrent Prostate Cancer after Radical Prostatectomy: The SALV-ENZA Trial. J Clin Oncol 41 (2023) 1307-1317**. PMID: 36367998.
* - these authors contributed equally; and + - senior authors
** - Highlighted by ASTRO Daily News, CancerNetwork, UroToday and VJOncology.
Philip Sutera, Amol C. Shetty, Alex Hakansson, Kim Van der Eecken, Yang Song, Yang (Seagle) Liu, Jinhee Chang, Valérie Fonteyne, Adrianna A Mendes, Nicolaas Lumen, Louke Delrue, Sofie Verbeke, Kathia De Man, Theresa Hodges, Anis Hamid, Nicholas Roberts, Daniel Y Song, Kenneth Pienta, Ashely Ross, Felix Feng, Steven Joniau, Daniel Spratt, Silke Gillessen, Gerhardt Attard, Nicholas D. James, Tamara Lotan, Elai Davicioni, Christopher Sweeney, Phuoc T. Tran, Matthew P. Deek+, Piet Ost+. Transcriptomic and clinical heterogeneity of metastatic disease timing within metastatic castration-sensitive prostate cancer. Ann Oncol 34 (2023) 605-614. PMID: 37164128.
+ - corresponding authors
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