Epithelial Plasticity in Cancer

Phuoc T. Tran*+, Emelyn H. Shroff*, Timothy F. Burns*, Saravanan Thiyagarajan, Sandhya T. Das, Tahera Zabuawala, Joy Chen, Yoon-Jae Cho, Richard Luong, Pablo Tamayo, Tarek Salih, Khaled Aziz, Stacey J. Adam, Silvestre Vicent, Carsten H. Nielsen, Nadia Withofs, Alejandro Sweet-Cordero, Sanjiv S. Gambhir, Charles M. Rudin and Dean W. Felsher+. Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis. PLoS Genet 8 (2012) e1002650. PMID: 22654667; PMCID: PMC3360067.
* - these authors contributed equally.

+ - corresponding authors.

Timothy F. Burns, Irina Dobromilskaya, Sara C. Murphy, Rajendra P. Gajula, Saravanan Thiyagarajan, Sarah S. Chatley, Khaled Aziz, Yoon-Jae Cho, Phuoc T. Tran, Charles M. Rudin. Inhibition of TWIST1 Leads to Activation of Oncogene-Induced Senescence in Oncogene Driven Non-Small Cell Lung Cancer. Mol Cancer Res 11 (2013) 329-338. PMID: 23364532.  PMCID: PMC3631276.

Rajendra P. Gajula*, Sivarajan T. Chettiar*, Russell D. Williams, Saravanan Thiyagarajan, Yoshinori Kato, Khaled Aziz, Ruoqi Wang, Nishant Gandhi, Aaron T. Wild, Farhad Vesuna, Jinfang Ma, Tarek Salih, Jessica Cades, Elana Fertig, Shyam Biswal, Timothy F. Burns, Christine Chung, Charles M. Rudin, Joseph M. Herman, Russell K. Hales, Venu Raman, Steven An, Phuoc T. Tran.  The twist box domain is required for Twist1-induced prostate cancer metastasis. Mol Cancer Res 11 (2013) 1387-1400**. PMID: 23982216. PMCID: PMC3833995.

* - these authors contributed equally.

** - Cover illustration and Highlighted in Mol Cancer Res.

Eliah R. Shamir, Elisa Pappalardo, Danielle M. Jorgens, Kester Coutinho, Wen-Ting Tsai, Khaled Aziz, Manfred Auer, Phuoc T. Tran, Joel S. Bader, Andrew J. Ewald.  Twist1-induced dissemination preserves epithelial identity and requires E-cadherin.  J Cell Biol 204 (2014) 839-856**.  PMID 24590176; PMCID: PMC3941052.

** - Cover illustration and Highlighted in J Cell Biol; rated Exceptional by Faculty of 1000 (http://f1000.com/prime/718297809).

Rajendra P. Gajula*, Sivarajan T. Chettiar*,  Russell D. Williams, Katriana Nugent, Yoshinori Kato, Hailun Wang, Reem Malek, Kekoa Taparra, Jessica Cades, Anvesh Annadanam, A-Rum Yoon, Elana Fertig, Beth A. Firulli, Lucia Mazzacurati, Timothy F. Burns, Anthony B. Firulli, Steven An, Phuoc T. Tran.  Structure-function studies of the bHLH phosphorylation domain of Twist1 in prostate cancer cellsNeoplasia 17 (2015) 16-31.  PMID: 25622896.  PMCID: PMC4309734.

* - these authors contributed equally.

Kekoa A. Taparra, Phuoc T. Tran, Natasha Zachara.  Hijacking the hexosamine biosynthetic pathway to promote epithelial-mesenchymal transition-mediated neoplastic phenotypesFront Oncol 6 (2016) 85.  PMID: 27148477. PMCID: PMC4834358. PMCID: PMC4834358.

 

Reem Malek*, Hailun Wang*, Kekoa Taparra, Phuoc T. Tran.  Therapeutic targeting of epithelial plasticity programs – Focus on the epithelial-mesenchymal transitionCells Tissues Organs 203 (2017) 114-127. PMID: 28214899.

* - these authors contributed equally

Reem Malek*, Rajendra P. Gajula*,  Russell D. Williams*, Belinda Nghiem, Brian W. Simons, Katriana Nugent, Hailun Wang, Kekoa Taparra, Ghali Lemtiri-Chlieh, A-Rum Yoon, Lawrence True, Steven S. An, Theodore L. DeWeese, Ashley Ross, Edward M. Schaeffer, Kenneth J. Pienta, Paula J. Hurley, Colm Morrissey, Phuoc T. Tran.  TWIST1-WDR5-Hottip regulates Hoxa9 chromatin to facilitate prostate cancer metastasisCancer Res  77 (2017) 3181-3193**.  PMID 28484075.  PMCID: PMC5489316.  

* - these authors contributed equally.

** - Highlighted in Cancer Res – Breaking Advances.

Zachary A. Yochum*, Jessica A. Cades*, Lucia  Mazzacurati, Neil Neumann, Susheel Khetarpal, Suman Chatterjee, Hailun Wang, Myriam Attar, Eric Huang, Sarah Chatley, Katriana Nugent, Ashwin Somasundaram, Johnathan Engh, Andrew Ewald, Yoon-Jae Cho, Charles M. Rudin,  Phuoc T. Tran, Timothy F. Burns. A First-in-Class TWIST1 inhibitor with Activity in Oncogene-driven Lung Cancer.  Mol Cancer Res 15 (2017) 1764-1776.  PMID 28851812.

* - these authors contributed equally.

Kekoa Taparra*, Hailun Wang*, Reem Malek*, Audrey Lafargue, Mustafa A. Barbhuiya, Xing Wang, Brian W. Simons, Matthew Ballew, Katriana Nugent, Jennifer Groves, Russell D. Williams, Takumi Shiraishi, James Verdone, Gokben Yildirir, Roger Henry, Bin Zhang, John Wong, Ken K. Wang, Barry D. Nelkin, Kenneth J. Pienta, Dean Felsher, Natasha E. Zachara+, Phuoc T. Tran+.  O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis. J Clin Invest 128 (2018) 4924-4937**. PMID 30130254. PMCID: PMC6205381.

* - these authors contributed equally.

+ - corresponding authors.

** - Highlighted in Cancer Res – Breaking Advances.

Zachary A. Yochum*, Jessica Cades*, Hailun Wang*, Suman Chatterjee, Brian W. Simons, James P. O'Brien, Susheel K. Khetarpal, Ghali Lemtiri-Chlieh, Kayla V. Myers, Eric H.-B. Huang, Charles M. Rudin, Phuoc T. Tran+, Timothy F. Burns+.  Targeting the EMT transcription factor TWIST1 overcomes resistance to EGFR inhibitors in EGFR-mutant non-small cell lung cancer. Oncogene 38 (2019) 656-670. PMID 30171258.  PMCID: PMC6358506.
* - these authors contributed equally.

+ - corresponding authors.

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Molecular Targeted Therapies, Immunotherapies and Radiosensitizers

Phuoc T. Tran*, Pavan K. Bendapudi*, H. Jill Lin*, Peter Choi, Shan Koh, Joy Chen, George Horng, Nicholas P. Hughes, Lawrence H. Schwartz, Vincent A. Miller, Toshiyuki Kawashima, Toshio Kitamura, David Paik+ and Dean W. Felsher+.  Survival and Death Signals Can Predict Tumor Response to Therapy After Oncogene InactivationSci Transl Med 3 (2011) 103ra99**.  PMID: 21974937; PMCID: PMC3966995.

* - these authors contributed equally; and + - corresponding authors.

** - Highlighted by Comments in Sci Transl Med, Cancer Res, Nat Rev Clin Oncol and Cancer Discovery

Jing Zeng, Khaled Aziz, Sivarajan T. Chettiar, Blake Aftab, Michael Armour, Rajendra Gajula, Nishant Gandhi, Tarek Salih, Joseph M. Herman, John Wong, Charles M. Rudin, Phuoc T. Tran, Russell K. Hales. Hedgehog pathway inhibition radiosensitizes non-small cell lung cancers. Int J Radiat Oncol Biol Phys 86 (2013) 143-149. PMID: 23182391.  PMCID: PMC4145860.

Nishant Gandhi*, Aaron T. Wild*,  Sivarajan T. Chettiar, Khaled Aziz, Yoshinori Kato, Rajendra P. Gajula, Russell D. Williams, Jessica Cades, Anvesh Annadanam, Danny Song, Yonggang Zhang, Russell K. Hales, Joseph M. Herman, Theodore L. DeWeese, Edward M. Schaeffer, Phuoc T. Tran.  Novel Hsp90 inhibitor NVP-AUY922 radiosensitizes prostate cancer cells. Cancer Biol Ther 14 (2013) 347-356. PMID: 23358469.

* - these authors contributed equally

Jing Zeng, Timothy J. Harris, Michael Lim, Charles G. Drake, Phuoc T. Tran.  Immune Modulation and Stereotactic Radiation – Improving Local and Abscopal Responses. Biomed Res Int 2013 (2013). 658126.  PMID: 24324970; PMCID: PMC3845488

Jing Zeng, Alfred P. See, Jillian Phallen, Christopher M. Jackson, Zineb Belcaid, Jacob Ruzevick, Nicholas Durham, Christian Meyer, Timothy J. Harris, Emilia Albesiano, Gustavo Pradilla, Eric Ford, John Wong, Hans Hammers, Dimitris Mathios, Betty Tyler, Henry Brem, Phuoc T. Tran, Drew Pardoll, Charles G. Drake, Michael Lim.  Anti-PD-1 blockade and stereotactic radiation produce long term survivors in mice with intracranial gliomas. Int J Radiat Oncol Biol Phys 86 (2013) 343-349**.  PMID: 23462419; PMCID: PMC3963403.

** - #2 “Top Download” biology paper from Int J Radiat Oncol Biol Phys in 2013 (http://www.redjournal.org/article/S0360-3016(14)00577-X/fulltext).

Aaron T. Wild*, Nishant Gandhi*, Sivarajan T. Chettiar, Khaled Aziz, Rajendra P. Gajula, Russell D. Williams, Rachit Kumar, Kekoa Taparra, Jing Zeng,  Jessica A, Cades, Esteban Velarde, Siddharth Menon, Jean-Francois Geschwind, David Cosgrove, Timothy M. Pawlik, Anirban Maitra, John Wong, Russell K. Hales, Michael Torbenson,  Joseph M. Herman+, Phuoc T. Tran+.  Concurrent versus sequential sorafenib therapy in combination with radiation for hepatocellular carcinomaPLoS ONE 8 (2013) e65726. PMID: 23762417. PMCID: PMC3675179.

* - these authors contributed equally; and + - corresponding authors.

Guus Martinus Bol, Farhad Vesuna, Min Xie, Jing Zeng, Khaled Aziz, Nishant Gandhi, Anne Levine, Ashley Irving, Dorian Korz, Saritha Tantravedi, Marise Heerma van Voss, Kathleen Gabrielson, Evan A. Bordt, Brian M. Polster, Leslie Cope, Petra van der Groep, Atul Kondaskar, Michelle A. Rudek, Ramachandra S. Hosmane, Elsken van der Wall, Paul Joannes van Diest, Phuoc T. Tran, Venu Raman.  Targeting DDX3 with a small molecule inhibitor for lung cancer therapy. EMBO Mol Med 7 (2015) 648-669**. PMID: 25820276.  PMCID: PMC4492822.

** - Highlighted in Cancer Res – Breaking Advances.

 

Sivarajan T. Chettiar*, Reem Malek*, Anvesh Annadanam*, Katriana Nugent, Yoshinori Kato, Hailun Wang, Jessica A. Cades, Kekoa Taparra, Zineb Belcaid, Matthew Ballew, Sarah Manmiller, David Proia, Michael Lim, Robert Anders, Joseph M. Herman, Phuoc T. Tran.  Ganetespib radiosensitization for liver cancer therapy.  Cancer Biol Ther 17 (2016) 457-66. PMID: 26980196.

* - these authors contributed equally

Zachary A. Yochum*, Jessica A. Cades*, Lucia  Mazzacurati, Neil Neumann, Susheel Khetarpal, Suman Chatterjee, Hailun Wang, Myriam Attar, Eric Huang, Sarah Chatley, Katriana Nugent, Ashwin Somasundaram, Johnathan Engh, Andrew Ewald, Yoon-Jae Cho, Charles M. Rudin,  Phuoc T. Tran, Timothy F. Burns. A First-in-Class TWIST1 inhibitor with Activity in Oncogene-driven Lung Cancer.  Mol Cancer Res 15 (2017) 1764-1776.  PMID 28851812.

* - these authors contributed equally.

Mustafa A. Barbhuiya*, Adam C. Mirando*, Brian W. Simons, Ghali Lemtiri-Chlieh, Jordan J. Green, Aleksander S. Popel+, Niranjan B. Pandey+,  Phuoc T. Tran+. Therapeutic potential of an anti-angiogenic multimodal biomimetic peptide in hepatocellular carcinomaOncotarget 8 (2017) 101520-101534.  PMID 29254183.  PMCID: PMC5731893.

* - these authors contributed equally; and + - corresponding authors.

Ariel Marciscano*, Heather McGee*, Joseph Walker*,  Michelle Kim, Charles Kunos, Arta Monjazeb, Stephen Shiao, Phuoc T. Tran+, Mansoor Ahmed+. Incorporating Radiation Oncology into Immunotherapy: Proceedings from the ASTRO-SITC-NCI Immunotherapy Workshop J Immunother Cancer 6 (2018) 6.  PMID: 29375032. PMCID: PMC5787916.

* - these authors contributed equally; and + - corresponding authors.

Robert Bristow, Brian Alexander, Michael Baumann, Scott V. Bratman, Martin Brown, Kevin Camphausen, Peter Choyke, Deborah Citrin, Joseph Contessa, Adam Dicker, David G. Kirsch, Mechthild Krause, Quynh Le, Michael Milosevic, Zachary Morris, Jann Sarkaria, Paul Sondel, Phuoc T. Tran, George Wilson, Henning Willers, Rebecca Wong, Paul M. Harari. Combining Precision Radiotherapy with Molecular Targeting and Immunomodulatory Agents.  Lancet Oncol 19 (2018) e240-e251. PMID: 29726389

Saif S. Ahmad, Marka Crittenden, Phuoc T. Tran, Paul Kluetz, Gideon Blumenthal, Helen Bulbeck, Richard D. Baird, Kaye J. Williams, Timothy Illidge, Stephen M. Hahn, Theodore S. Lawrence, Patricia A. Spears, Amanda J. Walker+, Ricky A. Sharma+.  Clinical Development of Novel Drug-Radiotherapy CombinationsClin Cancer Res 25 (2019). 1455-1461. PMID: 30498095.  PMCID: PMC6397668.

+ - corresponding authors

Ashley E. Ross, Paula J. Hurley, Phuoc T. Tran, Steven Rowe, Benjamin Benzon, Tanya O’Neal, Carolyn Chapman, Rana Harb, Yelena Milman, Charles G. Drake, Emmanuel S. Antonarakis. A Pilot Clinical Trial of Pembrolizumab plus Prostatic Cryotherapy for Men with Newly Diagnosed Oligometastatic Hormone-Sensitive Prostate Cancer. Prostate Cancer Prostatic Dis (2019). In press. PMID: 31611635.

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Small Animal Models, Imaging and Irradiation

Hu Zhou, Manuel Rodriguez, Fred van den Haak, Geoffrey Nelson, Rahil Jogani, Jiali Xu, Xinzhi Zhu, Yongjiang Xian, Phuoc T. Tran, Dean W. Felsher, Paul J. Keall, Edward E. Graves. Development of a MicroCT-Based Image-Guided Conformal Radiotherapy System for Small Animals. Int J Radiat Oncol Biol Phys 78 (2010)297-305. PMID: 20395069; PMCID: PMC2906632.

Edward E. Graves, Marta Vilalta, Ivana K. Cecic, Janine T. Erler, Phuoc T. Tran, Dean Felsher, Leanne Sayles, Alejandro Sweet-Cordero Quynh-Thu Le and Amato J. Giaccia. Hypoxia in models of lung cancer: implications for targeted therapeutics. Clin Cancer Res 16 (2010) 4843-52. PMID: 20858837; PMCID: PMC2948600.

Carsten H. Nielsen, Richard H Kimura, Nadia Withofs, Phuoc T. Tran, Zheng Miao, Jennifer Cochran, Zhen Cheng, Dean Felsher, Andreas Kjaer, Juergen K. Willmann, Sanjiv S. Gambhir. PET Imaging of Tumor Neovascularization in a Transgenic Mouse Model with a Novel 64Cu-DOTA-Knottin Peptide. Cancer Res 70 (2010) 9022-30. PMID: 21062977; PMCID: PMC3057960.

Phuoc T. Tran*, Pavan K. Bendapudi*, H. Jill Lin*, Peter Choi, Shan Koh, Joy Chen, George Horng, Nicholas P. Hughes, Lawrence H. Schwartz, Vincent A. Miller, Toshiyuki Kawashima, Toshio Kitamura, David Paik+ and Dean W. Felsher+.  Survival and Death Signals Can Predict Tumor Response to Therapy After Oncogene InactivationSci Transl Med 3 (2011) 103ra99**.  PMID: 21974937; PMCID: PMC3966995.

* - these authors contributed equally; and + - corresponding authors.

** - Highlighted by Comments in Sci Transl Med, Cancer Res, Nat Rev Clin Oncol and Cancer Discovery

Phuoc T. Tran*+, Emelyn H. Shroff*, Timothy F. Burns*, Saravanan Thiyagarajan, Sandhya T. Das, Tahera Zabuawala, Joy Chen, Yoon-Jae Cho, Richard Luong, Pablo Tamayo, Tarek Salih, Khaled Aziz, Stacey J. Adam, Silvestre Vicent, Carsten H. Nielsen, Nadia Withofs, Alejandro Sweet-Cordero, Sanjiv S. Gambhir, Charles M. Rudin and Dean W. Felsher+. Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis. PLoS Genet 8 (2012) e1002650. PMID: 22654667; PMCID: PMC3360067.
* - these authors contributed equally; and + - corresponding authors.

Bin Zhang, Ken Kang-Hsin Wang, Jingjing Yu, Sohrab Eslami, Phuoc T. Tran, Iulian Iordachita, Michael S. Patterson, John W. Wong.  Bioluminescence tomography guided radiation therapy for preclinical research. Int J Radiat Oncol Biol Phys 94 (2016) 1144-53**. PMID: 26876954. PMCID: PMC4814325.

** - Highlighted in Medical Physics Web (http://medicalphysicsweb.org/cws/article/research/64139).

Kekoa Taparra*, Hailun Wang*, Reem Malek*, Audrey Lafargue, Mustafa A. Barbhuiya, Xing Wang, Brian W. Simons, Matthew Ballew, Katriana Nugent, Jennifer Groves, Russell D. Williams, Takumi Shiraishi, James Verdone, Gokben Yildirir, Roger Henry, Bin Zhang, John Wong, Ken K. Wang, Barry D. Nelkin, Kenneth J. Pienta, Dean Felsher, Natasha E. Zachara+, Phuoc T. Tran+.  O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis. J Clin Invest 128 (2018) 4924-4937**. PMID 30130254. PMCID: PMC6205381.

* - these authors contributed equally.

+ - corresponding authors.

** - Highlighted in Cancer Res – Breaking Advances.

Zachary A. Yochum*, Jessica Cades*, Hailun Wang*, Suman Chatterjee, Brian W. Simons, James P. O'Brien, Susheel K. Khetarpal, Ghali Lemtiri-Chlieh, Kayla V. Myers, Eric H.-B. Huang, Charles M. Rudin, Phuoc T. Tran+, Timothy F. Burns+.  Targeting the EMT transcription factor TWIST1 overcomes resistance to EGFR inhibitors in EGFR-mutant non-small cell lung cancer. Oncogene 38 (2019) 656-670. PMID 30171258.  PMCID: PMC6358506.

* - these authors contributed equally.

+ - corresponding authors.

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Clinical Studies

Phuoc T. Tran+, Russell K. Hales, Jing Zeng, Khaled Aziz , Tarek Salih, Rajendra P. Gajula, Sivarajan Chettiar, Nishant Gandhi, Aaron T. Wild, Rachit Kumar, Joseph M. Herman, Danny Song and Theodore L. DeWeese. Tissue Biomarkers for Prostate Cancer Radiation Therapy. Curr Mol Med 12 (2012) 772-787. PMID: 22292443; PMCID: PMC3412203.
+ - corresponding author.

Nicholas Trakul, Christine Chang, Jeremy Harris, Christopher H. Chapman, Aarti Rao, John Shen, Sean Quinlan-Davidson, Edith J. Filion, Heather Wakelee, A. Dimitrios Colevas, Richard I. Whyte, Sonja Dieterich, Peter G. Maxim, Phuoc Tran, Quynh-Thu Le, Billy W. Loo, Jr., Maximilian Diehn. Tumor volume-adapted dosing in stereotactic ablative radiotherapy of lung tumors. Int J Radiat Oncol Biol 84 (2012) 231-7. PMID: 22381907.​

​​

Joseph M. Herman*, Aaron T. Wild*, Hao Wang, Phuoc T. Tran, Kenneth J. Chang, Gretchen E. Taylor, Ross C. Donehower, Timothy M. Pawlik, Mark A. Ziegler, Hongyan Cai, Dionne T. Savage, Yolanda M. Davis, Marcia I. Canto, Jason Klapman, Anthony Reid, Raj J. Shah, Sarah E Hoffe, Alexander Rosemurgy, Christopher L. Wolfgang, Daniel A. Laheru.  A randomized phase III multi-institutional study of TNFerade™ biologic with 5-fluorouracil and radiotherapy for locally advanced pancreatic cancer: Final results.  J Clin Oncol 31 (2013) 886-894.  PMID: 23341531.  PMCID: PMC4820756.

* - these authors contributed equally

Wolfgang Lilleby*, Amol Narrang*, Gunnar Tafjord, Ljiljana Vlatkovic, Kjell Magne Russnes, Andreas Stensvold, Knut Håkon Hole, Phuoc Tran, Karsten Eilertsen.  Favorable outcomes in locally advanced and node positive prostate cancer patients treated with combined pelvic IMRT and androgen deprivation therapy.  Radiat Oncol 10 (2015) 232. PMID: 26577452. PMCID: PMC4650510.

* - these authors contributed equally

Andrew J. Armstrong, Susan Halabi, Patrick Healy, W. Robert Lee, Bridget F. Koontz, Judd W. Moul, Kelly Mundy, Patricia Creel, Sarah Yenser Wood, Kristen Davis, Michael A. Carducci, Mark N. Stein, Brooke Reimer, Avery N. Spitz, Minh Nguyen, Ellen Bratt, Sung Kim, Phuoc T. Tran, Daniel J. George.  A phase 2 multimodality trial of docetaxel/prednisone with sunitinib followed by salvage radiation therapy in men with PSA recurrent prostate cancer after radical prostatectomyProstate Cancer Prostatic Dis 19 (2016) 100-106. PMID: 26754260.

Jeffrey J. Tosoian, Michael A. Gorin, Ashley E. Ross, Kenneth J. Pienta, Phuoc T. Tran, Edward M. Schaeffer. Oligometastatic Prostate Cancer: Definitions, Clinical Outcomes, and Treatment Considerations. Nat Rev Urol 14 (2017) 15-25.  PMID: 27725639.

Noura Radwan*, Ryan Phillips*, Ashley Ross, Steven Rowe, Michael Gorin, Emmanuel S. Antonarakis, Curtiland Deville, Stephen Greco, Samuel Denmeade, Channing Paller, Danny Y. Song, Hao Wang, Kenneth J. Pienta, Martin G. Pomper, Theodore L. DeWeese, Mario Eisenberger*, Phuoc T. Tran*.  Phase II Randomized Observation versus Stereotactic Ablative RadiatIon for OLigometastatic Prostate CancEr (ORIOLE) TrialBMC Cancer 17 (2017) 453.  PMID 28662647.

* - these authors contributed equally

Full Protocol

Phuoc T. Tran, Emmanuel S. Antonarakis. Altering the natural history of oligometastatic prostate cancer with local therapies: Reality versus Illusion.  J Oncol Pract 13 (2017) 21-24. PMID: 28045614.  PMCID: PMC5455151.

Elise De Bleser, Phuoc T. Tran, Piet Ost.  Radiotherapy as metastasis-directed therapy for oligometastatic prostate cancer.  Curr Opin Urol 27 (2017) 587-595.  PMID: 28816714.

Jonathan Hayman*, Ryan Phillips*, Di Chen, Jamie Perin, Amol K. Narang, Janson Trieu, Noura Radwan, Stephen Greco, Curtiland DeVille, Todd McNutt, Daniel Y. Song, Theodore L. DeWeese, Phuoc T. Tran.  Detectable end of radiation prostate specific antigen assists in identifying men with unfavorable intermediate-risk prostate cancer at high risk of distant recurrence and cancer-specific mortality.  Prostate 78 (2018) 623-30. PMID 29520847

* - these authors contributed equally

C. Leigh Moyer, Ryan Phillips, Matthew P. Deek, Noura Radwan, Ashley E. Ross, Emmanuel S. Antonarakis, Diane Reyes, Jean Wright, Stephanie A. Terezakis, Daniel Y. Song, Curtiland DeVille, Patrick C. Walsh, Theodore L. DeWeese, Michael Carducci, Edward M. Schaeffer, Kenneth J. Pienta, Mario Eisenberger+, Phuoc T. Tran+.  Stereotactic Ablative Radiation Therapy for Oligometastatic Prostate Cancer Delays Time to Next Systemic TreatmentWorld J Urol (2019). In press. PMID 30191396.

+ - corresponding authors

Matthew P. Deek*, Colburn Yu*, Ryan Phillips, Daniel Y. Song, Curtiland DeVille, Stephen Greco, Theodore L. DeWeese, Emmanuel S. Antonarakis, Mark Markowski, Channing Paller, Samuel Denmeade, Michael Carducci, Patrick C. Walsh, Kenneth J. Pienta, Mario Eisenberger, Phuoc T. Tran.  Radiotherapy in the definitive management of oligometastatic prostate cancer: the Johns Hopkins experience. Int J Radiat Oncol Biol Phys (2019).  In press. PMID 31419509.

* - these authors contributed equally

+ - corresponding authors

Ashley E. Ross, Paula J. Hurley, Phuoc T. Tran, Steven Rowe, Benjamin Benzon, Tanya O’Neal, Carolyn Chapman, Rana Harb, Yelena Milman, Charles G. Drake, Emmanuel S. Antonarakis. A Pilot Clinical Trial of Pembrolizumab plus Prostatic Cryotherapy for Men with Newly Diagnosed Oligometastatic Hormone-Sensitive Prostate Cancer. Prostate Cancer Prostatic Dis (2019). In press. PMID: 31611635.

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