About the Tran Lab
Dr. Tran and his laboratory have been continuously funded by the federal government (NIH and DoD) and foundations for a decade to study tumor cell epithelial plasticity programs such as the epithelial-mesenchymal transition (EMT) and the implications these programs have on tumorigenesis, metastasis, metabolism, cancer treatment resistance and radiation-induced fibrosis. Our research utilizes a variety of transgenic mouse models, non-invasive imaging as well as traditional molecular, biochemical and cell biology approaches.
Another major focus of the laboratory is the use of inducible mouse models to simulate molecularly targeted therapies for malignancies and radiation-induced late effects.
The laboratory also studies novel targeted agents as tumor selective radiosensitizers to increase the therapeutic ratio of clinical radiotherapy.