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Noninvasive Detection of Treatment
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Advanced Preclinical Mouse Models
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TWIST1 Mutant Transcriptome
Twist1-Hoxa9 UGM
Twist1 Expressing Mouse Models
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Sorafenib Treatment Schemes

Welcome to the Johns Hopkins Tran Lab  (tranlaboratory.com) Website

The Tran Lab's overarching goal is to translate our basic findings into novel approaches to improve the prevention, diagnosis, and treatment of human malignancies by studying...





Pathways critical for the development, progression, and maintenance of

prostate, lung, and liver tumors.

Transitions between epithelial and mesenchymal cellular states and their implications for tumorigenesis, metastasis, metabolism, treatment resistance, and radiation-induced fibrosis.

Novel targeted agents as tumor selective radiosensitizers to increase the therapeutic ratio of clinical radiotherapy.

Sorafenib Treatment Schemes

Sorafenib given sequentially with radiation increases the proportion of cells undergoing apoptosis compared to RT alone in vitro, while concurrent sorafenib-radiation does not.